Lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3 (SLC46A3)
Homo sapiens — UniProt Q7Z3Q1
Data last refreshed: (UniProt release unknown)
Key facts
Lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3 (SLC46A3) is a protein from Homo sapiens identified by UniProt accession Q7Z3Q1, 461 residues long. MolForge cross-references it against 0 known binders and 46 disease associations.
- UniProt accession: Q7Z3Q1; gene symbol SLC46A3.
- Organism: Homo sapiens.
- Length: 461 amino acids.
- Top disease associations (Open Targets): prostate carcinoma, Familial prostate cancer and prostate cancer.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3 |
|---|---|
| UniProt accession | Q7Z3Q1 |
| Gene | SLC46A3 |
| Organism | Homo sapiens |
| Length | 461 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (46)
Diseases linked to this target (Open Targets).
- prostate carcinoma · score 0.11
- Familial prostate cancer · score 0.11
- prostate cancer · score 0.11
- Steinert myotonic dystrophy · score 0.07
- BMI-adjusted waist-hip ratio · score 0.06
- triglyceride measurement · score 0.06
- fetal genotype effect measurement · score 0.05
- preeclampsia · score 0.05
- hepatocellular carcinoma · score 0.04
- cholesterol-ester transfer protein deficiency · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z3Q1-F1 | alphafold | PREDICTED | 86.89 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z3Q1.
Amino-acid sequence (461 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SLC46A3?
The strongest Open Targets associations for SLC46A3 are prostate carcinoma, Familial prostate cancer, prostate cancer, Steinert myotonic dystrophy and BMI-adjusted waist-hip ratio.
How long is the SLC46A3 protein?
The Homo sapiens SLC46A3 protein (UniProt Q7Z3Q1) is 461 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z3Q1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z3Q1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.