Voltage-dependent calcium channel subunit alpha-2/delta-4 (CACNA2D4)
Homo sapiens — UniProt Q7Z3S7
Data last refreshed: (UniProt release unknown)
Key facts
Voltage-dependent calcium channel subunit alpha-2/delta-4 (CACNA2D4) is a protein from Homo sapiens identified by UniProt accession Q7Z3S7, 1137 residues long. MolForge cross-references it against 0 known binders and 123 disease associations.
- UniProt accession: Q7Z3S7; gene symbol CACNA2D4.
- Organism: Homo sapiens.
- Length: 1137 amino acids.
- Top disease associations (Open Targets): Cone rod dystrophy, cardiovascular disease and generalized anxiety disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Voltage-dependent calcium channel subunit alpha-2/delta-4 |
|---|---|
| UniProt accession | Q7Z3S7 |
| Gene | CACNA2D4 |
| Organism | Homo sapiens |
| Length | 1137 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (123)
Diseases linked to this target (Open Targets).
- Cone rod dystrophy · score 0.66
- cardiovascular disease · score 0.46
- generalized anxiety disorder · score 0.39
- gastrointestinal disease · score 0.37
- inherited retinal dystrophy · score 0.37
- Polyuria · score 0.37
- congenital stationary night blindness · score 0.37
- Urinary incontinence · score 0.37
- retinitis pigmentosa · score 0.36
- cone-rod dystrophy · score 0.33
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z3S7-F1 | alphafold | PREDICTED | 81.37 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z3S7.
Amino-acid sequence (1137 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CACNA2D4?
The strongest Open Targets associations for CACNA2D4 are Cone rod dystrophy, cardiovascular disease, generalized anxiety disorder, gastrointestinal disease and inherited retinal dystrophy.
How long is the CACNA2D4 protein?
The Homo sapiens CACNA2D4 protein (UniProt Q7Z3S7) is 1137 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z3S7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z3S7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.