Zinc finger FYVE domain-containing protein 16 (ZFYVE16)
Homo sapiens — UniProt Q7Z3T8
Data last refreshed: (UniProt release unknown)
Key facts
Zinc finger FYVE domain-containing protein 16 (ZFYVE16) is a protein from Homo sapiens identified by UniProt accession Q7Z3T8, 1539 residues long. MolForge cross-references it against 0 known binders and 57 disease associations.
- UniProt accession: Q7Z3T8; gene symbol ZFYVE16.
- Organism: Homo sapiens.
- Length: 1539 amino acids.
- Top disease associations (Open Targets): Cerebral arteriovenous malformation, psoriasis and hair colour measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Zinc finger FYVE domain-containing protein 16 |
|---|---|
| UniProt accession | Q7Z3T8 |
| Gene | ZFYVE16 |
| Organism | Homo sapiens |
| Length | 1539 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (57)
Diseases linked to this target (Open Targets).
- Cerebral arteriovenous malformation · score 0.27
- psoriasis · score 0.19
- hair colour measurement · score 0.18
- hair color · score 0.17
- Dextrocardia · score 0.14
- lean body mass · score 0.09
- common variable immunodeficiency · score 0.05
- combined immunodeficiency with skin granulomas · score 0.05
- isolated agammaglobulinemia · score 0.05
- immunodeficiency 18 · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z3T8-F1 | alphafold | PREDICTED | 54.58 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z3T8.
Amino-acid sequence (1539 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ZFYVE16?
The strongest Open Targets associations for ZFYVE16 are Cerebral arteriovenous malformation, psoriasis, hair colour measurement, hair color and Dextrocardia.
How long is the ZFYVE16 protein?
The Homo sapiens ZFYVE16 protein (UniProt Q7Z3T8) is 1539 amino acids long.
Browse: Targets: Z · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z3T8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z3T8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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