Protein MON2 homolog (MON2)

Homo sapiens — UniProt Q7Z3U7

Gene: MON2Homo sapiensSwissProt reviewed

Data last refreshed: 2026-04-18 (UniProt release unknown)

Key facts

Protein MON2 homolog (MON2) is a protein from Homo sapiens identified by UniProt accession Q7Z3U7, 1717 residues long. MolForge cross-references it against 0 known binders and 50 disease associations.

UniProt accession: Q7Z3U7; gene symbol MON2.
Organism: Homo sapiens.
Length: 1717 amino acids.
Top disease associations (Open Targets): neurodegenerative disease, triglyceride measurement and lysosomal storage disease.
3D structure: AlphaFold model available.

Target properties

Protein name	Protein MON2 homolog
UniProt accession	Q7Z3U7
Gene	MON2
Organism	Homo sapiens
Length	1717 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (50)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.56
triglyceride measurement · score 0.38
lysosomal storage disease · score 0.37
BMI-adjusted waist-hip ratio · score 0.37
cortical surface area measurement · score 0.24
hypertension · score 0.21
balding measurement · score 0.10
cardiovascular disease · score 0.10
vital capacity · score 0.09
sex hormone-binding globulin measurement · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q7Z3U7-F1	alphafold	PREDICTED	77.93	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z3U7.

Amino-acid sequence (1717 residues)

MSGTSSPEAV KKLLENMQSD LRALSLECKK KFPPVKEAAE SGIIKVKTIA ARNTEILAAL KENSSEVVQP FLMGCGTKEP KITQLCLAAI QRLMSHEVVS ETAAGNIINM LWQLMENSLE ELKLLQTVLV LLTTNTVVHD EALSKAIVLC FRLHFTKDNI TNNTAAATVR QVVTVVFERM VAEDERHRDI IEQPVLVQGN SNRRSVSTLK PCAKDAYMLF QDLCQLVNAD APYWLVGMTE MTRTFGLELL ESVLNDFPQV FLQHQEFSFL LKERVCPLVI KLFSPNIKFR QGSSTSSSPA PVEKPYFPIC MRLLRVVSVL IKQFYSLLVT ECEIFLSLLV KFLDADKPQW LRAVAVESIH RFCVQPQLLR SFCQSYDMKQ HSTKVFRDIV NALGSFIQSL FLVPPTGNPA TSNQAGNNNL GGSVSAPANS GMVGIGGGVT LLPAFEYRGT WIPILTITVQ GSAKATYLEM LDKVEPPTIP EGYAMSVAFH CLLDLVRGIT SMIEGELGEL ETECQTTTEE GSSPTQSTEQ QDLQSTSDQM DKEIVSRAVW EEMVNACWCG LLAALSLLLD ASTDEAATEN ILKAELTMAA LCGRLGLVTS RDAFITAICK GSLPPHYALT VLNTTTAATL SNKSYSVQGQ SVMMISPSSE SHQQVVAVGQ PLAVQPQGTV MLTSKNIQCM RTLLNLAHCH GAVLGTSWQL VLATLQHLVW ILGLKPSSGG ALKPGRAVEG PSTVLTTAVM TDLPVISNIL SRLFESSQYL DDVSLHHLIN ALCSLSLEAM DMAYGNNKEP SLFAVAKLLE TGLVNMHRIE ILWRPLTGHL LEVCQHPNSR MREWGAEALT SLIKAGLTFN HDPPLSQNQR LQLLLLNPLK EMSNINHPDI RLKQLECVLQ ILQSQGDSLG PGWPLVLGVM GAIRNDQGES LIRTAFQCLQ LVVTDFLPTM PCTCLQIVVD VAGSFGLHNQ ELNISLTSIG LLWNISDYFF QRGETIEKEL NKEEAAQQKQ AEEKGVVLNR PFHPAPPFDC LWLCLYAKLG ELCVDPRPAV RKSAGQTLFS TIGAHGTLLQ HSTWHTVIWK VLFHLLDRVR ESSTTADKEK IESGGGNILI HHSRDTAEKQ WAETWVLTLA GVARIFNTRR YLLQPLGDFS RAWDVLLDHI QSAALSKNNE VSLAALKSFQ EILQIVSPVR DSDKPETPPV VNVPVPVLIG PISGMSRPFV RTDSIGEKLG RYSSSEPPIV TDELEDLNLW WAAWNTWYRI GSESTKPPIT FDKLTFIPSQ PFLTALIQIF PALYQHIKTG FNMDDLQKLG VILHSAISVP ISSDASPFIL PSYTEAVLTS LQEAVLTALD VLQKAICVGP ENMQIMYPAI FDQLLAFVEF SCKPPQYGQL ETKHIANAKY NQIQLFAPAE WVALNYVPFA ERSLEVVVDL YQKTACHKAV VNEKVLQNII KTLRVPLSLK YSCPSESTWK LAVSSLLRVL SIGLPVARQH ASSGKFDSMW PELANTFEDF LFTKSIPPDN LSIQEFQRNE NIDVEVVQLI SNEILPYANF IPKEFVGQIM TMLNKGSIHS QSSSFTEAEI DIRLREEFSK MCFETLLQFS FSNKVTTPQE GYISRMALSV LLKRSQDVLH RYIEDERLSG KCPLPRQQVT EIIFVLKAVS TLIDSLKKTQ PENVDGNTWA QVIALYPTLV ECITCSSSEV CSALKEALVP FKDFMQPPAS RVQNGES

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

Which diseases are associated with MON2?

The strongest Open Targets associations for MON2 are neurodegenerative disease, triglyceride measurement, lysosomal storage disease, BMI-adjusted waist-hip ratio and cortical surface area measurement.

How long is the MON2 protein?

The Homo sapiens MON2 protein (UniProt Q7Z3U7) is 1717 amino acids long.

Browse: Targets: M · all protein targets A–Z · drugs A–Z.

Sources

UniProtKB Q7Z3U7 — name, gene, function, sequence, keywords (CC BY 4.0)
AlphaFold DB Q7Z3U7 — predicted 3D structure (CC BY 4.0)
Open Targets Platform — disease associations and tractability (CC0)

How this page is built: methodology · editorial policy & corrections.

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