Ubiquitin-protein ligase E3B (UBE3B)
Homo sapiens — UniProt Q7Z3V4
Data last refreshed: (UniProt release unknown)
Key facts
Ubiquitin-protein ligase E3B (UBE3B) is a protein from Homo sapiens identified by UniProt accession Q7Z3V4, 1068 residues long. MolForge cross-references it against 0 known binders and 312 disease associations.
- UniProt accession: Q7Z3V4; gene symbol UBE3B.
- Organism: Homo sapiens.
- Length: 1068 amino acids.
- Top disease associations (Open Targets): oculocerebrofacial syndrome, Kaufman type, genetic disorder and Blepharophimosis-intellectual disability syndrome due to UBE3B deficiency.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ubiquitin-protein ligase E3B |
|---|---|
| UniProt accession | Q7Z3V4 |
| Gene | UBE3B |
| Organism | Homo sapiens |
| Length | 1068 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (312)
Diseases linked to this target (Open Targets).
- oculocerebrofacial syndrome, Kaufman type · score 0.76
- genetic disorder · score 0.49
- Blepharophimosis-intellectual disability syndrome due to UBE3B deficiency · score 0.46
- blepharophimosis - intellectual disability syndrome · score 0.34
- high density lipoprotein cholesterol measurement · score 0.32
- body mass index · score 0.29
- total cholesterol measurement · score 0.29
- monocyte count · score 0.28
- alcohol drinking · score 0.25
- apolipoprotein A 1 measurement · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z3V4-F1 | alphafold | PREDICTED | 84.71 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z3V4.
Amino-acid sequence (1068 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with UBE3B?
The strongest Open Targets associations for UBE3B are oculocerebrofacial syndrome, Kaufman type, genetic disorder, Blepharophimosis-intellectual disability syndrome due to UBE3B deficiency, blepharophimosis - intellectual disability syndrome and high density lipoprotein cholesterol measurement.
How long is the UBE3B protein?
The Homo sapiens UBE3B protein (UniProt Q7Z3V4) is 1068 amino acids long.
Browse: Targets: U · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z3V4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z3V4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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