Keratin, type I cytoskeletal 28 (KRT28)
Homo sapiens — UniProt Q7Z3Y7
Data last refreshed: (UniProt release unknown)
Key facts
Keratin, type I cytoskeletal 28 (KRT28) is a protein from Homo sapiens identified by UniProt accession Q7Z3Y7, 464 residues long. MolForge cross-references it against 0 known binders and 16 disease associations.
- UniProt accession: Q7Z3Y7; gene symbol KRT28.
- Organism: Homo sapiens.
- Length: 464 amino acids.
- Top disease associations (Open Targets): glioblastoma multiforme, clear cell renal carcinoma and head and neck squamous cell carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Keratin, type I cytoskeletal 28 |
|---|---|
| UniProt accession | Q7Z3Y7 |
| Gene | KRT28 |
| Organism | Homo sapiens |
| Length | 464 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (16)
Diseases linked to this target (Open Targets).
- glioblastoma multiforme · score 0.18
- clear cell renal carcinoma · score 0.18
- head and neck squamous cell carcinoma · score 0.18
- ovarian cancer · score 0.18
- breast adenocarcinoma · score 0.18
- esophageal cancer · score 0.14
- low grade glioma · score 0.11
- Kimura disease · score 0.04
- sebaceous of Jadassohn nevus · score 0.03
- immunodeficiency 75 · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z3Y7-F1 | alphafold | PREDICTED | 74.62 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z3Y7.
Amino-acid sequence (464 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KRT28?
The strongest Open Targets associations for KRT28 are glioblastoma multiforme, clear cell renal carcinoma, head and neck squamous cell carcinoma, ovarian cancer and breast adenocarcinoma.
How long is the KRT28 protein?
The Homo sapiens KRT28 protein (UniProt Q7Z3Y7) is 464 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z3Y7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z3Y7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.