Keratin, type I cytoskeletal 27 (KRT27)
Homo sapiens — UniProt Q7Z3Y8
Data last refreshed: (UniProt release unknown)
Key facts
Keratin, type I cytoskeletal 27 (KRT27) is a protein from Homo sapiens identified by UniProt accession Q7Z3Y8, 459 residues long. MolForge cross-references it against 0 known binders and 96 disease associations.
- UniProt accession: Q7Z3Y8; gene symbol KRT27.
- Organism: Homo sapiens.
- Length: 459 amino acids.
- Top disease associations (Open Targets): prostate adenocarcinoma, clear cell renal carcinoma and ovarian cancer.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Keratin, type I cytoskeletal 27 |
|---|---|
| UniProt accession | Q7Z3Y8 |
| Gene | KRT27 |
| Organism | Homo sapiens |
| Length | 459 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (96)
Diseases linked to this target (Open Targets).
- prostate adenocarcinoma · score 0.18
- clear cell renal carcinoma · score 0.18
- ovarian cancer · score 0.18
- head and neck squamous cell carcinoma · score 0.18
- neuroblastoma · score 0.13
- low grade glioma · score 0.11
- uncombable hair syndrome · score 0.10
- ringed hair disease · score 0.09
- pili bifurcati · score 0.09
- wooly hair, autosomal recessive 3 · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z3Y8-F1 | alphafold | PREDICTED | 74.97 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z3Y8.
Amino-acid sequence (459 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KRT27?
The strongest Open Targets associations for KRT27 are prostate adenocarcinoma, clear cell renal carcinoma, ovarian cancer, head and neck squamous cell carcinoma and neuroblastoma.
How long is the KRT27 protein?
The Homo sapiens KRT27 protein (UniProt Q7Z3Y8) is 459 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z3Y8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z3Y8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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