Keratin, type I cytoskeletal 26 (KRT26)
Homo sapiens — UniProt Q7Z3Y9
Data last refreshed: (UniProt release unknown)
Key facts
Keratin, type I cytoskeletal 26 (KRT26) is a protein from Homo sapiens identified by UniProt accession Q7Z3Y9, 468 residues long. MolForge cross-references it against 0 known binders and 9 disease associations.
- UniProt accession: Q7Z3Y9; gene symbol KRT26.
- Organism: Homo sapiens.
- Length: 468 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, head and neck squamous cell carcinoma and clear cell renal carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Keratin, type I cytoskeletal 26 |
|---|---|
| UniProt accession | Q7Z3Y9 |
| Gene | KRT26 |
| Organism | Homo sapiens |
| Length | 468 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (9)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.19
- head and neck squamous cell carcinoma · score 0.18
- clear cell renal carcinoma · score 0.18
- prostate adenocarcinoma · score 0.18
- hyperpigmentation with or without hypopigmentation, familial progressive · score 0.04
- sebaceous of Jadassohn nevus · score 0.03
- metabolite measurement · score 0.02
- visceral Leishmaniasis · score 0.00
- oral squamous cell carcinoma · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z3Y9-F1 | alphafold | PREDICTED | 74.21 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z3Y9.
Amino-acid sequence (468 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KRT26?
The strongest Open Targets associations for KRT26 are neurodegenerative disease, head and neck squamous cell carcinoma, clear cell renal carcinoma, prostate adenocarcinoma and hyperpigmentation with or without hypopigmentation, familial progressive.
How long is the KRT26 protein?
The Homo sapiens KRT26 protein (UniProt Q7Z3Y9) is 468 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z3Y9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z3Y9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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