Keratin, type I cytoskeletal 25 (KRT25)
Homo sapiens — UniProt Q7Z3Z0
Data last refreshed: (UniProt release unknown)
Key facts
Keratin, type I cytoskeletal 25 (KRT25) is a protein from Homo sapiens identified by UniProt accession Q7Z3Z0, 450 residues long. MolForge cross-references it against 0 known binders and 90 disease associations.
- UniProt accession: Q7Z3Z0; gene symbol KRT25.
- Organism: Homo sapiens.
- Length: 450 amino acids.
- Top disease associations (Open Targets): wooly hair, autosomal recessive 3, Woolly hair and hypotrichosis simplex.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Keratin, type I cytoskeletal 25 |
|---|---|
| UniProt accession | Q7Z3Z0 |
| Gene | KRT25 |
| Organism | Homo sapiens |
| Length | 450 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (90)
Diseases linked to this target (Open Targets).
- wooly hair, autosomal recessive 3 · score 0.63
- Woolly hair · score 0.52
- hypotrichosis simplex · score 0.35
- glioblastoma multiforme · score 0.19
- prostate adenocarcinoma · score 0.18
- head and neck squamous cell carcinoma · score 0.18
- ovarian cancer · score 0.18
- breast adenocarcinoma · score 0.18
- esophageal cancer · score 0.14
- neuroblastoma · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z3Z0-F1 | alphafold | PREDICTED | 74.12 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z3Z0.
Amino-acid sequence (450 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KRT25?
The strongest Open Targets associations for KRT25 are wooly hair, autosomal recessive 3, Woolly hair, hypotrichosis simplex, glioblastoma multiforme and prostate adenocarcinoma.
How long is the KRT25 protein?
The Homo sapiens KRT25 protein (UniProt Q7Z3Z0) is 450 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z3Z0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z3Z0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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