Piwi-like protein 3 (PIWIL3)
Homo sapiens — UniProt Q7Z3Z3
Data last refreshed: (UniProt release unknown)
Key facts
Piwi-like protein 3 (PIWIL3) is a protein from Homo sapiens identified by UniProt accession Q7Z3Z3, 882 residues long. MolForge cross-references it against 0 known binders and 37 disease associations.
- UniProt accession: Q7Z3Z3; gene symbol PIWIL3.
- Organism: Homo sapiens.
- Length: 882 amino acids.
- Top disease associations (Open Targets): serum gamma-glutamyl transferase measurement, spinal muscular atrophy and genetic disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Piwi-like protein 3 |
|---|---|
| UniProt accession | Q7Z3Z3 |
| Gene | PIWIL3 |
| Organism | Homo sapiens |
| Length | 882 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (37)
Diseases linked to this target (Open Targets).
- serum gamma-glutamyl transferase measurement · score 0.30
- spinal muscular atrophy · score 0.15
- genetic disorder · score 0.12
- neoplasm · score 0.09
- Atrophy/Degeneration affecting the central nervous system · score 0.08
- pachyonychia congenita · score 0.04
- cancer · score 0.02
- hepatocellular carcinoma · score 0.02
- infection · score 0.01
- infect · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z3Z3-F1 | alphafold | PREDICTED | 83.25 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z3Z3.
Amino-acid sequence (882 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PIWIL3?
The strongest Open Targets associations for PIWIL3 are serum gamma-glutamyl transferase measurement, spinal muscular atrophy, genetic disorder, neoplasm and Atrophy/Degeneration affecting the central nervous system.
How long is the PIWIL3 protein?
The Homo sapiens PIWIL3 protein (UniProt Q7Z3Z3) is 882 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z3Z3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z3Z3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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