Piwi-like protein 4 (PIWIL4)
Homo sapiens — UniProt Q7Z3Z4
Data last refreshed: (UniProt release unknown)
Key facts
Piwi-like protein 4 (PIWIL4) is a protein from Homo sapiens identified by UniProt accession Q7Z3Z4, 852 residues long. MolForge cross-references it against 0 known binders and 176 disease associations.
- UniProt accession: Q7Z3Z4; gene symbol PIWIL4.
- Organism: Homo sapiens.
- Length: 852 amino acids.
- Top disease associations (Open Targets): IGF-1 measurement, blood protein measurement and cutaneous melanoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Piwi-like protein 4 |
|---|---|
| UniProt accession | Q7Z3Z4 |
| Gene | PIWIL4 |
| Organism | Homo sapiens |
| Length | 852 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (176)
Diseases linked to this target (Open Targets).
- IGF-1 measurement · score 0.28
- blood protein measurement · score 0.24
- cutaneous melanoma · score 0.15
- neurofibrillary tangles measurement · score 0.14
- breast adenocarcinoma · score 0.09
- neoplasm · score 0.09
- azoospermia · score 0.09
- cancer · score 0.08
- male infertility with teratozoospermia due to single gene mutation · score 0.07
- partial chromosome Y deletion · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z3Z4-F1 | alphafold | PREDICTED | 85.23 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z3Z4.
Amino-acid sequence (852 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PIWIL4?
The strongest Open Targets associations for PIWIL4 are IGF-1 measurement, blood protein measurement, cutaneous melanoma, neurofibrillary tangles measurement and breast adenocarcinoma.
How long is the PIWIL4 protein?
The Homo sapiens PIWIL4 protein (UniProt Q7Z3Z4) is 852 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z3Z4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z3Z4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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