Mitochondrial antiviral-signaling protein (MAVS)
Homo sapiens — UniProt Q7Z434
Data last refreshed: (UniProt release unknown)
Key facts
Mitochondrial antiviral-signaling protein (MAVS) is a protein from Homo sapiens identified by UniProt accession Q7Z434, 540 residues long. MolForge cross-references it against 0 known binders and 356 disease associations.
- UniProt accession: Q7Z434; gene symbol MAVS.
- Organism: Homo sapiens.
- Length: 540 amino acids.
- Top disease associations (Open Targets): severe acute respiratory syndrome, neurodegenerative disease and COVID-19.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Mitochondrial antiviral-signaling protein |
|---|---|
| UniProt accession | Q7Z434 |
| Gene | MAVS |
| Organism | Homo sapiens |
| Length | 540 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (356)
Diseases linked to this target (Open Targets).
- severe acute respiratory syndrome · score 0.50
- neurodegenerative disease · score 0.50
- COVID-19 · score 0.47
- viral disease · score 0.39
- platelet component distribution width · score 0.28
- breast adenocarcinoma · score 0.23
- head and neck squamous cell carcinoma · score 0.22
- urinary bladder cancer · score 0.20
- chronic lymphocytic leukemia · score 0.19
- gastric adenocarcinoma · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z434-F1 | alphafold | PREDICTED | 54.88 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z434.
Amino-acid sequence (540 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MAVS?
The strongest Open Targets associations for MAVS are severe acute respiratory syndrome, neurodegenerative disease, COVID-19, viral disease and platelet component distribution width.
How long is the MAVS protein?
The Homo sapiens MAVS protein (UniProt Q7Z434) is 540 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z434 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z434 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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