Nephrocystin-3 (NPHP3)
Homo sapiens — UniProt Q7Z494
Data last refreshed: (UniProt release unknown)
Key facts
Nephrocystin-3 (NPHP3) is a protein from Homo sapiens identified by UniProt accession Q7Z494, 1330 residues long. MolForge cross-references it against 0 known binders and 180 disease associations.
- UniProt accession: Q7Z494; gene symbol NPHP3.
- Organism: Homo sapiens.
- Length: 1330 amino acids.
- Top disease associations (Open Targets): nephronophthisis 3, NPHP3-related Meckel-like syndrome and renal-hepatic-pancreatic dysplasia 1.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Nephrocystin-3 |
|---|---|
| UniProt accession | Q7Z494 |
| Gene | NPHP3 |
| Organism | Homo sapiens |
| Length | 1330 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (180)
Diseases linked to this target (Open Targets).
- nephronophthisis 3 · score 0.81
- NPHP3-related Meckel-like syndrome · score 0.78
- renal-hepatic-pancreatic dysplasia 1 · score 0.75
- nephronophthisis · score 0.73
- renal-hepatic-pancreatic dysplasia · score 0.71
- Senior-Loken syndrome · score 0.66
- late-onset nephronophthisis · score 0.66
- Nephronophthisis · score 0.62
- Joubert syndrome and related disorders · score 0.48
- Meckel syndrome · score 0.41
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z494-F1 | alphafold | PREDICTED | 72.64 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z494.
Amino-acid sequence (1330 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NPHP3?
The strongest Open Targets associations for NPHP3 are nephronophthisis 3, NPHP3-related Meckel-like syndrome, renal-hepatic-pancreatic dysplasia 1, nephronophthisis and renal-hepatic-pancreatic dysplasia.
How long is the NPHP3 protein?
The Homo sapiens NPHP3 protein (UniProt Q7Z494) is 1330 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z494 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z494 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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