tRNA (guanine(10)-N(2))-methyltransferase TRMT11 (TRMT11)
Homo sapiens — UniProt Q7Z4G4
Data last refreshed: (UniProt release unknown)
Key facts
tRNA (guanine(10)-N(2))-methyltransferase TRMT11 (TRMT11) is a protein from Homo sapiens identified by UniProt accession Q7Z4G4, 463 residues long. MolForge cross-references it against 0 known binders and 50 disease associations.
- UniProt accession: Q7Z4G4; gene symbol TRMT11.
- Organism: Homo sapiens.
- Length: 463 amino acids.
- Top disease associations (Open Targets): heel bone mineral density, BMI-adjusted hip circumference and waist-hip ratio.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | tRNA (guanine(10)-N(2))-methyltransferase TRMT11 |
|---|---|
| UniProt accession | Q7Z4G4 |
| Gene | TRMT11 |
| Organism | Homo sapiens |
| Length | 463 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (50)
Diseases linked to this target (Open Targets).
- heel bone mineral density · score 0.39
- BMI-adjusted hip circumference · score 0.35
- waist-hip ratio · score 0.34
- BMI-adjusted waist-hip ratio · score 0.33
- neurodegenerative disease · score 0.28
- balding measurement · score 0.22
- hair shape measurement · score 0.21
- IGF-1 measurement · score 0.08
- sex hormone-binding globulin measurement · score 0.05
- body height · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z4G4-F1 | alphafold | PREDICTED | 88.42 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z4G4.
Amino-acid sequence (463 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TRMT11?
The strongest Open Targets associations for TRMT11 are heel bone mineral density, BMI-adjusted hip circumference, waist-hip ratio, BMI-adjusted waist-hip ratio and neurodegenerative disease.
How long is the TRMT11 protein?
The Homo sapiens TRMT11 protein (UniProt Q7Z4G4) is 463 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z4G4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z4G4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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