LIM and senescent cell antigen-like-containing domain protein 2 (LIMS2)
Homo sapiens — UniProt Q7Z4I7
Data last refreshed: (UniProt release unknown)
Key facts
LIM and senescent cell antigen-like-containing domain protein 2 (LIMS2) is a protein from Homo sapiens identified by UniProt accession Q7Z4I7, 341 residues long. MolForge cross-references it against 0 known binders and 60 disease associations.
- UniProt accession: Q7Z4I7; gene symbol LIMS2.
- Organism: Homo sapiens.
- Length: 341 amino acids.
- Top disease associations (Open Targets): autosomal recessive limb-girdle muscular dystrophy type 2W, autosomal recessive limb-girdle muscular dystrophy and lymphocyte count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | LIM and senescent cell antigen-like-containing domain protein 2 |
|---|---|
| UniProt accession | Q7Z4I7 |
| Gene | LIMS2 |
| Organism | Homo sapiens |
| Length | 341 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (60)
Diseases linked to this target (Open Targets).
- autosomal recessive limb-girdle muscular dystrophy type 2W · score 0.63
- autosomal recessive limb-girdle muscular dystrophy · score 0.50
- lymphocyte count · score 0.29
- myeloid white cell count · score 0.24
- breast adenocarcinoma · score 0.23
- leukocyte count · score 0.20
- endometrial cancer · score 0.18
- neutropenia · score 0.11
- lymphopenia · score 0.11
- head and neck squamous cell carcinoma · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z4I7-F1 | alphafold | PREDICTED | 86.74 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z4I7.
Amino-acid sequence (341 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LIMS2?
The strongest Open Targets associations for LIMS2 are autosomal recessive limb-girdle muscular dystrophy type 2W, autosomal recessive limb-girdle muscular dystrophy, lymphocyte count, myeloid white cell count and breast adenocarcinoma.
How long is the LIMS2 protein?
The Homo sapiens LIMS2 protein (UniProt Q7Z4I7) is 341 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z4I7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z4I7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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