Tripartite motif-containing protein 46 (TRIM46)
Homo sapiens — UniProt Q7Z4K8
Data last refreshed: (UniProt release unknown)
Key facts
Tripartite motif-containing protein 46 (TRIM46) is a protein from Homo sapiens identified by UniProt accession Q7Z4K8, 759 residues long. MolForge cross-references it against 0 known binders and 107 disease associations.
- UniProt accession: Q7Z4K8; gene symbol TRIM46.
- Organism: Homo sapiens.
- Length: 759 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, urate measurement and uric acid measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Tripartite motif-containing protein 46 |
|---|---|
| UniProt accession | Q7Z4K8 |
| Gene | TRIM46 |
| Organism | Homo sapiens |
| Length | 759 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (107)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.35
- urate measurement · score 0.32
- uric acid measurement · score 0.29
- vital capacity · score 0.29
- serum urea measurement · score 0.27
- calcium measurement · score 0.22
- serum gamma-glutamyl transferase measurement · score 0.21
- dentures · score 0.21
- acute myeloid leukemia · score 0.20
- breast carcinoma · score 0.20
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z4K8-F1 | alphafold | PREDICTED | 79.18 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z4K8.
Amino-acid sequence (759 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TRIM46?
The strongest Open Targets associations for TRIM46 are neurodegenerative disease, urate measurement, uric acid measurement, vital capacity and serum urea measurement.
How long is the TRIM46 protein?
The Homo sapiens TRIM46 protein (UniProt Q7Z4K8) is 759 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z4K8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z4K8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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