Tetratricopeptide repeat protein 21B (TTC21B)
Homo sapiens — UniProt Q7Z4L5
Data last refreshed: (UniProt release unknown)
Key facts
Tetratricopeptide repeat protein 21B (TTC21B) is a protein from Homo sapiens identified by UniProt accession Q7Z4L5, 1316 residues long. MolForge cross-references it against 0 known binders and 152 disease associations.
- UniProt accession: Q7Z4L5; gene symbol TTC21B.
- Organism: Homo sapiens.
- Length: 1316 amino acids.
- Top disease associations (Open Targets): nephronophthisis, Jeune syndrome and Infantile nephronophthisis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Tetratricopeptide repeat protein 21B |
|---|---|
| UniProt accession | Q7Z4L5 |
| Gene | TTC21B |
| Organism | Homo sapiens |
| Length | 1316 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (152)
Diseases linked to this target (Open Targets).
- nephronophthisis · score 0.76
- Jeune syndrome · score 0.74
- Infantile nephronophthisis · score 0.52
- Nephronophthisis · score 0.51
- Retinal dystrophy · score 0.45
- short-rib thoracic dysplasia 6 with or without polydactyly · score 0.44
- nephrotic syndrome · score 0.42
- Beemer-Langer syndrome · score 0.42
- genetic disorder · score 0.42
- Senior-Loken syndrome · score 0.40
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z4L5-F1 | alphafold | PREDICTED | 83.14 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z4L5.
Amino-acid sequence (1316 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TTC21B?
The strongest Open Targets associations for TTC21B are nephronophthisis, Jeune syndrome, Infantile nephronophthisis, Nephronophthisis and Retinal dystrophy.
How long is the TTC21B protein?
The Homo sapiens TTC21B protein (UniProt Q7Z4L5) is 1316 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z4L5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z4L5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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