Protein phosphatase 1 regulatory subunit 42 (PPP1R42)
Homo sapiens — UniProt Q7Z4L9
Data last refreshed: (UniProt release unknown)
Key facts
Protein phosphatase 1 regulatory subunit 42 (PPP1R42) is a protein from Homo sapiens identified by UniProt accession Q7Z4L9, 309 residues long. MolForge cross-references it against 0 known binders and 15 disease associations.
- UniProt accession: Q7Z4L9; gene symbol PPP1R42.
- Organism: Homo sapiens.
- Length: 309 amino acids.
- Top disease associations (Open Targets): autosomal recessive spondylocostal dysostosis, posterior fusion of lumbosacral vertebrae-blepharoptosis syndrome and brain aneurysm.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein phosphatase 1 regulatory subunit 42 |
|---|---|
| UniProt accession | Q7Z4L9 |
| Gene | PPP1R42 |
| Organism | Homo sapiens |
| Length | 309 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (15)
Diseases linked to this target (Open Targets).
- autosomal recessive spondylocostal dysostosis · score 0.07
- posterior fusion of lumbosacral vertebrae-blepharoptosis syndrome · score 0.07
- brain aneurysm · score 0.06
- Posterior fusion of lumbosacral vertebrae - blepharoptosis · score 0.05
- Klippel-Feil syndrome 3, autosomal dominant · score 0.04
- multiple synostoses syndrome 2 · score 0.04
- Prata-Liberal-Goncalves syndrome · score 0.04
- Microcephaly - cervical spine fusion anomalies · score 0.04
- microcephaly-cervical spine fusion anomalies syndrome · score 0.04
- gut microbiome measurement · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z4L9-F1 | alphafold | PREDICTED | 85.96 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z4L9.
Amino-acid sequence (309 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PPP1R42?
The strongest Open Targets associations for PPP1R42 are autosomal recessive spondylocostal dysostosis, posterior fusion of lumbosacral vertebrae-blepharoptosis syndrome, brain aneurysm, Posterior fusion of lumbosacral vertebrae - blepharoptosis and Klippel-Feil syndrome 3, autosomal dominant.
How long is the PPP1R42 protein?
The Homo sapiens PPP1R42 protein (UniProt Q7Z4L9) is 309 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z4L9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z4L9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.