Meiotic recombination protein REC114 (REC114)
Homo sapiens — UniProt Q7Z4M0
Data last refreshed: (UniProt release unknown)
Key facts
Meiotic recombination protein REC114 (REC114) is a protein from Homo sapiens identified by UniProt accession Q7Z4M0, 266 residues long. MolForge cross-references it against 0 known binders and 134 disease associations.
- UniProt accession: Q7Z4M0; gene symbol REC114.
- Organism: Homo sapiens.
- Length: 266 amino acids.
- Top disease associations (Open Targets): oocyte maturation defect 10, gut microbiome measurement and FEV/FVC ratio.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Meiotic recombination protein REC114 |
|---|---|
| UniProt accession | Q7Z4M0 |
| Gene | REC114 |
| Organism | Homo sapiens |
| Length | 266 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (134)
Diseases linked to this target (Open Targets).
- oocyte maturation defect 10 · score 0.51
- gut microbiome measurement · score 0.33
- FEV/FVC ratio · score 0.30
- response to cold medicine · score 0.21
- toxic epidermal necrolysis · score 0.21
- Stevens-Johnson syndrome · score 0.21
- azoospermia · score 0.08
- 46,XX testicular disorder of sex development · score 0.07
- partial chromosome Y deletion · score 0.07
- Testicular regression syndrome · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z4M0-F1 | alphafold | PREDICTED | 72.39 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z4M0.
Amino-acid sequence (266 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with REC114?
The strongest Open Targets associations for REC114 are oocyte maturation defect 10, gut microbiome measurement, FEV/FVC ratio, response to cold medicine and toxic epidermal necrolysis.
How long is the REC114 protein?
The Homo sapiens REC114 protein (UniProt Q7Z4M0) is 266 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z4M0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z4M0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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