Transient receptor potential cation channel subfamily M member 1 (TRPM1)
Homo sapiens — UniProt Q7Z4N2
Data last refreshed: (UniProt release unknown)
Key facts
Transient receptor potential cation channel subfamily M member 1 (TRPM1) is a protein from Homo sapiens identified by UniProt accession Q7Z4N2, 1603 residues long. MolForge cross-references it against 0 known binders and 158 disease associations.
- UniProt accession: Q7Z4N2; gene symbol TRPM1.
- Organism: Homo sapiens.
- Length: 1603 amino acids.
- Target class: Ion channel.
- Top disease associations (Open Targets): congenital stationary night blindness, Retinal dystrophy and sunburn.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transient receptor potential cation channel subfamily M member 1 |
|---|---|
| UniProt accession | Q7Z4N2 |
| Gene | TRPM1 |
| Organism | Homo sapiens |
| Length | 1603 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | Ion channel (inferred from UniProt keywords / EC) |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (158)
Diseases linked to this target (Open Targets).
- congenital stationary night blindness · score 0.70
- Retinal dystrophy · score 0.48
- sunburn · score 0.42
- PHF-tau measurement · score 0.42
- age-related macular degeneration · score 0.36
- skin pigmentation · score 0.34
- macula measurement · score 0.32
- reticulocyte count · score 0.32
- Red cell distribution width · score 0.32
- protein measurement · score 0.31
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z4N2-F1 | alphafold | PREDICTED | 66.28 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z4N2.
Amino-acid sequence (1603 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TRPM1?
The strongest Open Targets associations for TRPM1 are congenital stationary night blindness, Retinal dystrophy, sunburn, PHF-tau measurement and age-related macular degeneration.
How long is the TRPM1 protein?
The Homo sapiens TRPM1 protein (UniProt Q7Z4N2) is 1603 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z4N2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z4N2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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