Prolyl 4-hydroxylase subunit alpha-3 (P4HA3)
Homo sapiens — UniProt Q7Z4N8
Data last refreshed: (UniProt release unknown)
Key facts
Prolyl 4-hydroxylase subunit alpha-3 (P4HA3) is a protein from Homo sapiens identified by UniProt accession Q7Z4N8, 544 residues long. MolForge cross-references it against 0 known binders and 157 disease associations.
- UniProt accession: Q7Z4N8; gene symbol P4HA3.
- Organism: Homo sapiens.
- Length: 544 amino acids.
- Top disease associations (Open Targets): breast adenocarcinoma, hematocrit and mean corpuscular volume.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Prolyl 4-hydroxylase subunit alpha-3 |
|---|---|
| UniProt accession | Q7Z4N8 |
| Gene | P4HA3 |
| Organism | Homo sapiens |
| Length | 544 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (157)
Diseases linked to this target (Open Targets).
- breast adenocarcinoma · score 0.23
- hematocrit · score 0.11
- mean corpuscular volume · score 0.10
- neoplasm · score 0.10
- cancer · score 0.09
- hemoglobin measurement · score 0.08
- appendicular lean mass · score 0.08
- Familial short QT syndrome · score 0.07
- mean corpuscular hemoglobin concentration · score 0.07
- Arrhythmogenic right ventricular dysplasia · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z4N8-F1 | alphafold | PREDICTED | 88.29 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z4N8.
Amino-acid sequence (544 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with P4HA3?
The strongest Open Targets associations for P4HA3 are breast adenocarcinoma, hematocrit, mean corpuscular volume, neoplasm and cancer.
How long is the P4HA3 protein?
The Homo sapiens P4HA3 protein (UniProt Q7Z4N8) is 544 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z4N8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z4N8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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