Growth/differentiation factor 7 (GDF7)
Homo sapiens — UniProt Q7Z4P5
Data last refreshed: (UniProt release unknown)
Key facts
Growth/differentiation factor 7 (GDF7) is a protein from Homo sapiens identified by UniProt accession Q7Z4P5, 450 residues long. MolForge cross-references it against 0 known binders and 129 disease associations.
- UniProt accession: Q7Z4P5; gene symbol GDF7.
- Organism: Homo sapiens.
- Length: 450 amino acids.
- Top disease associations (Open Targets): prostate carcinoma, hemorrhoid and pulse pressure measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Growth/differentiation factor 7 |
|---|---|
| UniProt accession | Q7Z4P5 |
| Gene | GDF7 |
| Organism | Homo sapiens |
| Length | 450 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (129)
Diseases linked to this target (Open Targets).
- prostate carcinoma · score 0.35
- hemorrhoid · score 0.34
- pulse pressure measurement · score 0.33
- Barrett's esophagus · score 0.30
- esophageal adenocarcinoma · score 0.29
- neurodegenerative disease · score 0.29
- prolapse of female genital organ · score 0.24
- pelvic organ prolapse · score 0.24
- uterine prolapse · score 0.24
- serum urea measurement · score 0.24
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z4P5-F1 | alphafold | PREDICTED | 69.98 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z4P5.
Amino-acid sequence (450 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GDF7?
The strongest Open Targets associations for GDF7 are prostate carcinoma, hemorrhoid, pulse pressure measurement, Barrett's esophagus and esophageal adenocarcinoma.
How long is the GDF7 protein?
The Homo sapiens GDF7 protein (UniProt Q7Z4P5) is 450 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z4P5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z4P5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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