HEAT repeat-containing protein 3 (HEATR3)
Homo sapiens — UniProt Q7Z4Q2
Data last refreshed: (UniProt release unknown)
Key facts
HEAT repeat-containing protein 3 (HEATR3) is a protein from Homo sapiens identified by UniProt accession Q7Z4Q2, 680 residues long. MolForge cross-references it against 0 known binders and 67 disease associations.
- UniProt accession: Q7Z4Q2; gene symbol HEATR3.
- Organism: Homo sapiens.
- Length: 680 amino acids.
- Top disease associations (Open Targets): Blackfan-Diamond anemia, Intellectual disability and Obesity.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | HEAT repeat-containing protein 3 |
|---|---|
| UniProt accession | Q7Z4Q2 |
| Gene | HEATR3 |
| Organism | Homo sapiens |
| Length | 680 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (67)
Diseases linked to this target (Open Targets).
- Blackfan-Diamond anemia · score 0.49
- Intellectual disability · score 0.49
- Obesity · score 0.49
- Growth delay · score 0.49
- Abnormal thumb morphology · score 0.49
- obesity · score 0.49
- Abnormality of the face · score 0.49
- Abnormal finger morphology · score 0.49
- Abnormality of the skeletal system · score 0.49
- Thrombocytopenia · score 0.49
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z4Q2-F1 | alphafold | PREDICTED | 83.09 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z4Q2.
Amino-acid sequence (680 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with HEATR3?
The strongest Open Targets associations for HEATR3 are Blackfan-Diamond anemia, Intellectual disability, Obesity, Growth delay and Abnormal thumb morphology.
How long is the HEATR3 protein?
The Homo sapiens HEATR3 protein (UniProt Q7Z4Q2) is 680 amino acids long.
Browse: Targets: H · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z4Q2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z4Q2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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