SH2 domain-containing protein 6 (SH2D6)
Homo sapiens — UniProt Q7Z4S9
Data last refreshed: (UniProt release unknown)
Key facts
SH2 domain-containing protein 6 (SH2D6) is a protein from Homo sapiens identified by UniProt accession Q7Z4S9, 335 residues long. MolForge cross-references it against 0 known binders and 19 disease associations.
- UniProt accession: Q7Z4S9; gene symbol SH2D6.
- Organism: Homo sapiens.
- Length: 335 amino acids.
- Top disease associations (Open Targets): mean platelet volume, platelet count and uric acid measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | SH2 domain-containing protein 6 |
|---|---|
| UniProt accession | Q7Z4S9 |
| Gene | SH2D6 |
| Organism | Homo sapiens |
| Length | 335 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (19)
Diseases linked to this target (Open Targets).
- mean platelet volume · score 0.40
- platelet count · score 0.39
- uric acid measurement · score 0.22
- urate measurement · score 0.22
- adolescent idiopathic scoliosis · score 0.18
- platelet component distribution width · score 0.14
- blood protein measurement · score 0.07
- lymphocyte percentage of leukocytes · score 0.03
- Barrett's esophagus · score 0.02
- leukocyte count · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z4S9-F1 | alphafold | PREDICTED | 62.58 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z4S9.
Amino-acid sequence (335 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SH2D6?
The strongest Open Targets associations for SH2D6 are mean platelet volume, platelet count, uric acid measurement, urate measurement and adolescent idiopathic scoliosis.
How long is the SH2D6 protein?
The Homo sapiens SH2D6 protein (UniProt Q7Z4S9) is 335 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z4S9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z4S9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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