Inactive polypeptide N-acetylgalactosaminyltransferase-like protein 5 (GALNTL5)
Homo sapiens — UniProt Q7Z4T8
Data last refreshed: (UniProt release unknown)
Key facts
Inactive polypeptide N-acetylgalactosaminyltransferase-like protein 5 (GALNTL5) is a protein from Homo sapiens identified by UniProt accession Q7Z4T8, 443 residues long. MolForge cross-references it against 0 known binders and 128 disease associations.
- UniProt accession: Q7Z4T8; gene symbol GALNTL5.
- Organism: Homo sapiens.
- Length: 443 amino acids.
- Top disease associations (Open Targets): male infertility, azoospermia and male infertility with teratozoospermia due to single gene mutation.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Inactive polypeptide N-acetylgalactosaminyltransferase-like protein 5 |
|---|---|
| UniProt accession | Q7Z4T8 |
| Gene | GALNTL5 |
| Organism | Homo sapiens |
| Length | 443 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (128)
Diseases linked to this target (Open Targets).
- male infertility · score 0.29
- azoospermia · score 0.11
- male infertility with teratozoospermia due to single gene mutation · score 0.09
- partial chromosome Y deletion · score 0.08
- spermatogenic failure 65 · score 0.07
- spermatogenic failure 56 · score 0.07
- spermatogenic failure, X-linked, 3 · score 0.07
- spermatogenic failure 40 · score 0.07
- spermatogenic failure 11 · score 0.07
- spermatogenic failure 10 · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z4T8-F1 | alphafold | PREDICTED | 85.43 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z4T8.
Amino-acid sequence (443 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GALNTL5?
The strongest Open Targets associations for GALNTL5 are male infertility, azoospermia, male infertility with teratozoospermia due to single gene mutation, partial chromosome Y deletion and spermatogenic failure 65.
How long is the GALNTL5 protein?
The Homo sapiens GALNTL5 protein (UniProt Q7Z4T8) is 443 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z4T8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z4T8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.