Hepatoma-derived growth factor-related protein 2 (HDGFL2)
Homo sapiens — UniProt Q7Z4V5
Data last refreshed: (UniProt release unknown)
Key facts
Hepatoma-derived growth factor-related protein 2 (HDGFL2) is a protein from Homo sapiens identified by UniProt accession Q7Z4V5, 671 residues long. MolForge cross-references it against 0 known binders and 86 disease associations.
- UniProt accession: Q7Z4V5; gene symbol HDGFL2.
- Organism: Homo sapiens.
- Length: 671 amino acids.
- Top disease associations (Open Targets): mean corpuscular hemoglobin, platelet count and hemoglobin measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Hepatoma-derived growth factor-related protein 2 |
|---|---|
| UniProt accession | Q7Z4V5 |
| Gene | HDGFL2 |
| Organism | Homo sapiens |
| Length | 671 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (86)
Diseases linked to this target (Open Targets).
- mean corpuscular hemoglobin · score 0.26
- platelet count · score 0.26
- hemoglobin measurement · score 0.24
- sex hormone-binding globulin measurement · score 0.24
- mean corpuscular hemoglobin concentration · score 0.23
- reticulocyte count · score 0.23
- mean corpuscular volume · score 0.23
- erythrocyte count · score 0.20
- Immature Reticulocyte Fraction Measurement · score 0.20
- BMI-adjusted waist-hip ratio · score 0.20
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z4V5-F1 | alphafold | PREDICTED | 59.92 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z4V5.
Amino-acid sequence (671 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with HDGFL2?
The strongest Open Targets associations for HDGFL2 are mean corpuscular hemoglobin, platelet count, hemoglobin measurement, sex hormone-binding globulin measurement and mean corpuscular hemoglobin concentration.
How long is the HDGFL2 protein?
The Homo sapiens HDGFL2 protein (UniProt Q7Z4V5) is 671 amino acids long.
Browse: Targets: H · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z4V5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z4V5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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