L-xylulose reductase (DCXR)
Homo sapiens — UniProt Q7Z4W1
Data last refreshed: (UniProt release unknown)
Key facts
L-xylulose reductase (DCXR) is a protein from Homo sapiens identified by UniProt accession Q7Z4W1, 244 residues long. MolForge cross-references it against 0 known binders and 80 disease associations.
- UniProt accession: Q7Z4W1; gene symbol DCXR.
- Organism: Homo sapiens.
- Length: 244 amino acids.
- Top disease associations (Open Targets): pentosuria, neurodegenerative disease and neuroinflammatory disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | L-xylulose reductase |
|---|---|
| UniProt accession | Q7Z4W1 |
| Gene | DCXR |
| Organism | Homo sapiens |
| Length | 244 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (80)
Diseases linked to this target (Open Targets).
- pentosuria · score 0.61
- neurodegenerative disease · score 0.44
- neuroinflammatory disorder · score 0.43
- Disorder of carbohydrate metabolism · score 0.37
- vital capacity · score 0.10
- heel bone mineral density · score 0.06
- neoplasm · score 0.05
- hepatocellular carcinoma · score 0.05
- clear cell renal carcinoma · score 0.04
- erythrocyte count · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z4W1-F1 | alphafold | PREDICTED | 96.26 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z4W1.
Amino-acid sequence (244 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DCXR?
The strongest Open Targets associations for DCXR are pentosuria, neurodegenerative disease, neuroinflammatory disorder, Disorder of carbohydrate metabolism and vital capacity.
How long is the DCXR protein?
The Homo sapiens DCXR protein (UniProt Q7Z4W1) is 244 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z4W1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z4W1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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