ATP synthase subunit g 2, mitochondrial (ATP5MGL)
Homo sapiens — UniProt Q7Z4Y8
Data last refreshed: (UniProt release unknown)
Key facts
ATP synthase subunit g 2, mitochondrial (ATP5MGL) is a protein from Homo sapiens identified by UniProt accession Q7Z4Y8, 100 residues long. MolForge cross-references it against 0 known binders and 52 disease associations.
- UniProt accession: Q7Z4Y8; gene symbol ATP5MGL.
- Organism: Homo sapiens.
- Length: 100 amino acids.
- Top disease associations (Open Targets): hemoglobin D disease, dehydrated hereditary stomatocytosis and dominant beta-thalassemia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | ATP synthase subunit g 2, mitochondrial |
|---|---|
| UniProt accession | Q7Z4Y8 |
| Gene | ATP5MGL |
| Organism | Homo sapiens |
| Length | 100 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (52)
Diseases linked to this target (Open Targets).
- hemoglobin D disease · score 0.05
- dehydrated hereditary stomatocytosis · score 0.05
- dominant beta-thalassemia · score 0.04
- Hyperlipoproteinemia type 1 · score 0.04
- hemoglobin E-beta-thalassemia syndrome · score 0.04
- hemoglobin H disease · score 0.04
- Hemolytic anemia due to red cell pyruvate kinase deficiency · score 0.04
- Congenital dyserythropoietic anemia type I · score 0.04
- Blackfan-Diamond anemia · score 0.04
- hemoglobin E disease · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z4Y8-F1 | alphafold | PREDICTED | 81.91 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z4Y8.
Amino-acid sequence (100 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ATP5MGL?
The strongest Open Targets associations for ATP5MGL are hemoglobin D disease, dehydrated hereditary stomatocytosis, dominant beta-thalassemia, Hyperlipoproteinemia type 1 and hemoglobin E-beta-thalassemia syndrome.
How long is the ATP5MGL protein?
The Homo sapiens ATP5MGL protein (UniProt Q7Z4Y8) is 100 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z4Y8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z4Y8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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