Rho GTPase-activating protein 22 (ARHGAP22)
Homo sapiens — UniProt Q7Z5H3
Data last refreshed: (UniProt release unknown)
Key facts
Rho GTPase-activating protein 22 (ARHGAP22) is a protein from Homo sapiens identified by UniProt accession Q7Z5H3, 698 residues long. MolForge cross-references it against 0 known binders and 67 disease associations.
- UniProt accession: Q7Z5H3; gene symbol ARHGAP22.
- Organism: Homo sapiens.
- Length: 698 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, macula measurement and body height.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Rho GTPase-activating protein 22 |
|---|---|
| UniProt accession | Q7Z5H3 |
| Gene | ARHGAP22 |
| Organism | Homo sapiens |
| Length | 698 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (67)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.42
- macula measurement · score 0.33
- body height · score 0.32
- blood protein measurement · score 0.30
- diabetic retinopathy · score 0.29
- retinal layer thickness measurement · score 0.29
- retinal nerve fibre layer thickness measurement · score 0.23
- urate measurement · score 0.19
- bone density · score 0.19
- sex hormone-binding globulin measurement · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z5H3-F1 | alphafold | PREDICTED | 68.14 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z5H3.
Amino-acid sequence (698 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ARHGAP22?
The strongest Open Targets associations for ARHGAP22 are neurodegenerative disease, macula measurement, body height, blood protein measurement and diabetic retinopathy.
How long is the ARHGAP22 protein?
The Homo sapiens ARHGAP22 protein (UniProt Q7Z5H3) is 698 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z5H3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z5H3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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