Hydroxysteroid 11-beta-dehydrogenase 1-like protein (HSD11B1L)
Homo sapiens — UniProt Q7Z5J1
Data last refreshed: (UniProt release unknown)
Key facts
Hydroxysteroid 11-beta-dehydrogenase 1-like protein (HSD11B1L) is a protein from Homo sapiens identified by UniProt accession Q7Z5J1, 315 residues long. MolForge cross-references it against 0 known binders and 13 disease associations.
- UniProt accession: Q7Z5J1; gene symbol HSD11B1L.
- Organism: Homo sapiens.
- Length: 315 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, Red cell distribution width and mean corpuscular hemoglobin.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Hydroxysteroid 11-beta-dehydrogenase 1-like protein |
|---|---|
| UniProt accession | Q7Z5J1 |
| Gene | HSD11B1L |
| Organism | Homo sapiens |
| Length | 315 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (13)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.21
- Red cell distribution width · score 0.21
- mean corpuscular hemoglobin · score 0.17
- mean corpuscular volume · score 0.13
- mean corpuscular hemoglobin concentration · score 0.08
- mean reticulocyte volume · score 0.04
- mitochondrial DNA measurement · score 0.04
- body height · score 0.03
- erythrocyte count · score 0.03
- sitting height measurement · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z5J1-F1 | alphafold | PREDICTED | 72.34 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z5J1.
Amino-acid sequence (315 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with HSD11B1L?
The strongest Open Targets associations for HSD11B1L are neurodegenerative disease, Red cell distribution width, mean corpuscular hemoglobin, mean corpuscular volume and mean corpuscular hemoglobin concentration.
How long is the HSD11B1L protein?
The Homo sapiens HSD11B1L protein (UniProt Q7Z5J1) is 315 amino acids long.
Browse: Targets: H · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z5J1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z5J1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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