Wings apart-like protein homolog (WAPL)
Homo sapiens — UniProt Q7Z5K2
Data last refreshed: (UniProt release unknown)
Key facts
Wings apart-like protein homolog (WAPL) is a protein from Homo sapiens identified by UniProt accession Q7Z5K2, 1190 residues long. MolForge cross-references it against 0 known binders and 47 disease associations.
- UniProt accession: Q7Z5K2; gene symbol WAPL.
- Organism: Homo sapiens.
- Length: 1190 amino acids.
- Top disease associations (Open Targets): mathematical ability, breast milk measurement and acute myeloid leukemia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Wings apart-like protein homolog |
|---|---|
| UniProt accession | Q7Z5K2 |
| Gene | WAPL |
| Organism | Homo sapiens |
| Length | 1190 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (47)
Diseases linked to this target (Open Targets).
- mathematical ability · score 0.27
- breast milk measurement · score 0.19
- acute myeloid leukemia · score 0.18
- body mass index · score 0.16
- endometrial cancer · score 0.14
- neutrophil count · score 0.13
- cardiovascular disease · score 0.12
- Abnormal pinna morphology · score 0.12
- Abnormality of the outer ear · score 0.12
- Large for gestational age · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z5K2-F1 | alphafold | PREDICTED | 58.97 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z5K2.
Amino-acid sequence (1190 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with WAPL?
The strongest Open Targets associations for WAPL are mathematical ability, breast milk measurement, acute myeloid leukemia, body mass index and endometrial cancer.
How long is the WAPL protein?
The Homo sapiens WAPL protein (UniProt Q7Z5K2) is 1190 amino acids long.
Browse: Targets: W · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z5K2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z5K2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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