Transmembrane channel-like protein 3 (TMC3)
Homo sapiens — UniProt Q7Z5M5
Data last refreshed: (UniProt release unknown)
Key facts
Transmembrane channel-like protein 3 (TMC3) is a protein from Homo sapiens identified by UniProt accession Q7Z5M5, 1100 residues long. MolForge cross-references it against 0 known binders and 30 disease associations.
- UniProt accession: Q7Z5M5; gene symbol TMC3.
- Organism: Homo sapiens.
- Length: 1100 amino acids.
- Top disease associations (Open Targets): diastolic blood pressure, neurodegenerative disease and body height.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transmembrane channel-like protein 3 |
|---|---|
| UniProt accession | Q7Z5M5 |
| Gene | TMC3 |
| Organism | Homo sapiens |
| Length | 1100 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (30)
Diseases linked to this target (Open Targets).
- diastolic blood pressure · score 0.34
- neurodegenerative disease · score 0.33
- body height · score 0.23
- mean corpuscular volume · score 0.22
- basophil count · score 0.22
- mean corpuscular hemoglobin concentration · score 0.21
- mean corpuscular hemoglobin · score 0.21
- red blood cell density measurement · score 0.20
- erythrocyte count · score 0.18
- lymphocyte count · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z5M5-F1 | alphafold | PREDICTED | 59.88 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z5M5.
Amino-acid sequence (1100 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMC3?
The strongest Open Targets associations for TMC3 are diastolic blood pressure, neurodegenerative disease, body height, mean corpuscular volume and basophil count.
How long is the TMC3 protein?
The Homo sapiens TMC3 protein (UniProt Q7Z5M5) is 1100 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z5M5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z5M5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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