Protein ABHD12B (ABHD12B)
Homo sapiens — UniProt Q7Z5M8
Data last refreshed: (UniProt release unknown)
Key facts
Protein ABHD12B (ABHD12B) is a protein from Homo sapiens identified by UniProt accession Q7Z5M8, 362 residues long. MolForge cross-references it against 0 known binders and 32 disease associations.
- UniProt accession: Q7Z5M8; gene symbol ABHD12B.
- Organism: Homo sapiens.
- Length: 362 amino acids.
- Top disease associations (Open Targets): optic cup area measurement, rectum cancer and alkaline phosphatase measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein ABHD12B |
|---|---|
| UniProt accession | Q7Z5M8 |
| Gene | ABHD12B |
| Organism | Homo sapiens |
| Length | 362 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (32)
Diseases linked to this target (Open Targets).
- optic cup area measurement · score 0.31
- rectum cancer · score 0.29
- alkaline phosphatase measurement · score 0.10
- colorectal cancer · score 0.10
- sodium measurement · score 0.08
- acute lymphoblastic leukemia · score 0.08
- MODY · score 0.07
- hyperproinsulinemia · score 0.05
- glycogen storage disorder due to hepatic glycogen synthase deficiency · score 0.04
- Glycogen storage disease due to hepatic glycogen synthase deficiency · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z5M8-F1 | alphafold | PREDICTED | 87.79 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z5M8.
Amino-acid sequence (362 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ABHD12B?
The strongest Open Targets associations for ABHD12B are optic cup area measurement, rectum cancer, alkaline phosphatase measurement, colorectal cancer and sodium measurement.
How long is the ABHD12B protein?
The Homo sapiens ABHD12B protein (UniProt Q7Z5M8) is 362 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z5M8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z5M8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.