Protein sidekick-1 (SDK1)

Homo sapiens — UniProt Q7Z5N4

Gene: SDK1Homo sapiensSwissProt reviewed

Data last refreshed: 2026-04-18 (UniProt release unknown)

Key facts

Protein sidekick-1 (SDK1) is a protein from Homo sapiens identified by UniProt accession Q7Z5N4, 2213 residues long. MolForge cross-references it against 0 known binders and 63 disease associations.

UniProt accession: Q7Z5N4; gene symbol SDK1.
Organism: Homo sapiens.
Length: 2213 amino acids.
Top disease associations (Open Targets): mathematical ability, smoking status measurement and smoking behavior.
3D structure: AlphaFold model available.

Target properties

Protein name	Protein sidekick-1
UniProt accession	Q7Z5N4
Gene	SDK1
Organism	Homo sapiens
Length	2213 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (63)

Diseases linked to this target (Open Targets).

mathematical ability · score 0.45
smoking status measurement · score 0.44
smoking behavior · score 0.43
smoking initiation · score 0.41
wellbeing measurement · score 0.40
self reported educational attainment · score 0.40
age at first sexual intercourse measurement · score 0.38
motion sickness · score 0.36
insomnia measurement · score 0.36
depressive symptom measurement · score 0.35

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q7Z5N4-F1	alphafold	PREDICTED	72.17	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z5N4.

Amino-acid sequence (2213 residues)

MARGARPSAA GGGGGGAEPP ERAGPGRPRG SPPGRARPSL APRPGPEPSR PRAAPETSGG DTAGAGRCGG RRAAKLGPGR RGWWALLALQ LHLLRALAQD DVAPYFKTEP GLPQIHLEGN RLVLTCLAEG SWPLEFKWMR DDSELTTYSS EYKYIIPSLQ KLDAGFYRCV VRNRMGALLQ RKSEVQVAYM GSFMDTDQRK TVSQGRAAIL NLLPITSYPR PQVTWFREGH KIIPSNRIAI TLENQLVILA TTTSDAGAYY VQAVNEKNGE NKTSPFIHLS IARDVGTPET MAPTIVVPPG NRSVVAGSSE TTLECIASAR PVEDLSVTWK RNGVRITSGL HSFGRRLTIS NPTSADTGPY VCEAALPGSA FEPARATAFL FIIEPPYFTA EPESRISAEV EETVDIGCQA MGVPLPTLQW YKDAISISRL QNPRYKVLAS GGLRIQKLRP EDSGIFQCFA SNEGGEIQTH TYLDVTNIAP VFTQRPVDTT VTDGMTAILR CEVSGAPKPA ITWKRENHIL ASGSVRIPRF MLLESGGLQI APVFIQDAGN YTCYAANTEG SLNASATLTV WNRTSIVHPP EDHVVIKGTT ATLHCGATHD PRVSLRYVWK KDNVALTPSS TSRIVVEKDG SLLISQTWSG DIGDYSCEIV SEGGNDSRMA RLEVIELPHS PQNLLVSPNS SHSHAVVLSW VRPFDGNSPI LYYIVELSEN NSPWKVHLSN VGPEMTGVTV SGLTPARTYQ FRVCAVNEVG RGQYSAETSR LMLPEEPPSA PPKNIVASGR TNQSIMVQWQ PPPETEHNGV LRGYILRYRL AGLPGEYQQR NITSPEVNYC LVTDLIIWTQ YEIQVAAYNG AGLGVFSRAV TEYTLQGVPT APPQNVQTEA VNSTTIQFLW NPPPQQFING INQGYKLLAW PADAPEAVTV VTIAPDFHGV HHGHITNLKK FTAYFTSVLC FTTPGDGPPS TPQLVWTQED KPGAVGHLSF TEILDTSLKV SWQEPLEKNG IITGYQISWE VYGRNDSRLT HTLNSTTHEY KIQGLSSLTT YTIDVAAVTA VGTGLVTSST ISSGVPPDLP GAPSNLVISN ISPRSATLQF RPGYDGKTSI SRWIVEGQVG AIGDEEEWVT LYEEENEPDA QMLEIPNLTP YTHYRFRMKQ VNIVGPSPYS PSSRVIQTLQ APPDVAPTSV TVRTASETSL RLRWVPLPDS QYNGNPESVG YRIKYWRSDL QSSAVAQVVS DRLEREFTIE ELEEWMEYEL QMQAFNAVGA GPWSEVVRGR TRESVPSAAP ENVSAEAVSS TQILLTWTSV PEQDQNGLIL GYKILFRAKD LDPEPRSHIV RGNHTQSALL AGLRKFVLYE LQVLAFTRIG NGVPSTPLIL ERTKDDAPGP PVRLVFPEVR LTSVRIVWQP PEEPNGIILG YQIAYRLASS SPHTFTTVEV GATVRQFTAT DLAPESAYIF RLSAKTRQGW GEPLEATVIT TEKRERPAPP RELLVPQAEV TARSLRLQWV PGSDGASPIR YFTMQVRELP RGEWQTYSSS ISHEATACVV DRLRPFTSYK LRLKATNDIG DSDFSSETEA VTTLQDVPGE PPGSVSATPH TTSSVLIQWQ PPRDESLNGL LQGYRIYYRE LEYEAGSGTE AKTLKNPIAL HAELTAQSSF KTVNSSSTST MCELTHLKKY RRYEVIMTAY NIIGESPASA PVEVFVGEAA PAMAPQNVQV TPLTASQLEV TWDPPPPESQ NGNIQGYKIY YWEADSQNET EKMKVLFLPE PVVRLKNLTS HTKYLVSISA FNAAGDGPKS DPQQGRTHQA APGAPSFLAF SEITSTTLNV SWGEPAAANG ILQGYRVVYE PLAPVQGVSK VVTVEVRGNW QRWLKVRDLT KGVTYFFRVQ ARTITYGPEL QANITAGPAE GSPGSPRDVL VTKSASELTL QWTEGHSGDT PTTGYVIEAR PSDEGLWDMF VKDIPRSATS YTLSLDKLRQ GVTYEFRVVA VNEAGYGEPS NPSTAVSAQV EAPFYEEWWF LLVMALSSLI VILLVVFALV LHGQNKKYKN CSTGKGISTM EESVTLDNGG FAALELSSRH LNVKSTFSKK NGTRSPPRPS PGGLHYSDED ICNKYNGAVL TESVSLKEKS ADASESEATD SDYEDALPKH SFVNHYMSDP TYYNSWKRRA QGRAPAPHRY EAVAGSEAGA QLHPVITTQS AGGVYTPAGP GARTPLTGFS SFV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

Which diseases are associated with SDK1?

The strongest Open Targets associations for SDK1 are mathematical ability, smoking status measurement, smoking behavior, smoking initiation and wellbeing measurement.

How long is the SDK1 protein?

The Homo sapiens SDK1 protein (UniProt Q7Z5N4) is 2213 amino acids long.

Browse: Targets: S · all protein targets A–Z · drugs A–Z.

Sources

UniProtKB Q7Z5N4 — name, gene, function, sequence, keywords (CC BY 4.0)
AlphaFold DB Q7Z5N4 — predicted 3D structure (CC BY 4.0)
Open Targets Platform — disease associations and tractability (CC0)

How this page is built: methodology · editorial policy & corrections.

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