DNA polymerase nu (POLN)
Homo sapiens — UniProt Q7Z5Q5
Data last refreshed: (UniProt release unknown)
Key facts
DNA polymerase nu (POLN) is a protein from Homo sapiens identified by UniProt accession Q7Z5Q5, 900 residues long. MolForge cross-references it against 0 known binders and 31 disease associations.
- UniProt accession: Q7Z5Q5; gene symbol POLN.
- Organism: Homo sapiens.
- Length: 900 amino acids.
- Top disease associations (Open Targets): diastolic blood pressure, systolic blood pressure and body height.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | DNA polymerase nu |
|---|---|
| UniProt accession | Q7Z5Q5 |
| Gene | POLN |
| Organism | Homo sapiens |
| Length | 900 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (31)
Diseases linked to this target (Open Targets).
- diastolic blood pressure · score 0.39
- systolic blood pressure · score 0.38
- body height · score 0.32
- body weight · score 0.29
- high density lipoprotein cholesterol measurement · score 0.26
- body mass index · score 0.24
- lymphocyte count · score 0.19
- breast adenocarcinoma · score 0.18
- prostate carcinoma · score 0.11
- prostate cancer · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z5Q5-F1 | alphafold | PREDICTED | 75.25 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z5Q5.
Amino-acid sequence (900 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with POLN?
The strongest Open Targets associations for POLN are diastolic blood pressure, systolic blood pressure, body height, body weight and high density lipoprotein cholesterol measurement.
How long is the POLN protein?
The Homo sapiens POLN protein (UniProt Q7Z5Q5) is 900 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z5Q5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z5Q5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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