Amyloid beta A4 precursor protein-binding family B member 1-interacting protein (APBB1IP)
Homo sapiens — UniProt Q7Z5R6
Data last refreshed: (UniProt release unknown)
Key facts
Amyloid beta A4 precursor protein-binding family B member 1-interacting protein (APBB1IP) is a protein from Homo sapiens identified by UniProt accession Q7Z5R6, 666 residues long. MolForge cross-references it against 0 known binders and 198 disease associations.
- UniProt accession: Q7Z5R6; gene symbol APBB1IP.
- Organism: Homo sapiens.
- Length: 666 amino acids.
- Top disease associations (Open Targets): cancer, Noonan syndrome and hypertrophic cardiomyopathy.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Amyloid beta A4 precursor protein-binding family B member 1-interacting protein |
|---|---|
| UniProt accession | Q7Z5R6 |
| Gene | APBB1IP |
| Organism | Homo sapiens |
| Length | 666 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (198)
Diseases linked to this target (Open Targets).
- cancer · score 0.61
- Noonan syndrome · score 0.53
- hypertrophic cardiomyopathy · score 0.50
- Costello syndrome · score 0.50
- eosinophil count · score 0.50
- basophil count · score 0.48
- lymphocyte count · score 0.42
- reticulocyte count · score 0.42
- cardiofaciocutaneous syndrome · score 0.37
- eosinophil percentage of leukocytes · score 0.35
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z5R6-F1 | alphafold | PREDICTED | 71.78 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z5R6.
Amino-acid sequence (666 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with APBB1IP?
The strongest Open Targets associations for APBB1IP are cancer, Noonan syndrome, hypertrophic cardiomyopathy, Costello syndrome and eosinophil count.
How long is the APBB1IP protein?
The Homo sapiens APBB1IP protein (UniProt Q7Z5R6) is 666 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z5R6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z5R6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.