Bone morphogenetic protein 8A (BMP8A)
Homo sapiens — UniProt Q7Z5Y6
Data last refreshed: (UniProt release unknown)
Key facts
Bone morphogenetic protein 8A (BMP8A) is a protein from Homo sapiens identified by UniProt accession Q7Z5Y6, 402 residues long. MolForge cross-references it against 0 known binders and 163 disease associations.
- UniProt accession: Q7Z5Y6; gene symbol BMP8A.
- Organism: Homo sapiens.
- Length: 402 amino acids.
- Top disease associations (Open Targets): sex hormone-binding globulin measurement, alkaline phosphatase measurement and type 2 diabetes mellitus.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Bone morphogenetic protein 8A |
|---|---|
| UniProt accession | Q7Z5Y6 |
| Gene | BMP8A |
| Organism | Homo sapiens |
| Length | 402 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (163)
Diseases linked to this target (Open Targets).
- sex hormone-binding globulin measurement · score 0.34
- alkaline phosphatase measurement · score 0.32
- type 2 diabetes mellitus · score 0.23
- chronic obstructive pulmonary disease · score 0.22
- body weight · score 0.21
- sitting height measurement · score 0.21
- resting heart rate · score 0.19
- forced expiratory volume · score 0.19
- mean corpuscular volume · score 0.19
- triglyceride measurement · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z5Y6-F1 | alphafold | PREDICTED | 76.24 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z5Y6.
Amino-acid sequence (402 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with BMP8A?
The strongest Open Targets associations for BMP8A are sex hormone-binding globulin measurement, alkaline phosphatase measurement, type 2 diabetes mellitus, chronic obstructive pulmonary disease and body weight.
How long is the BMP8A protein?
The Homo sapiens BMP8A protein (UniProt Q7Z5Y6) is 402 amino acids long.
Browse: Targets: B · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z5Y6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z5Y6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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