B- and T-lymphocyte attenuator (BTLA)
Homo sapiens — UniProt Q7Z6A9
Data last refreshed: (UniProt release unknown)
Key facts
B- and T-lymphocyte attenuator (BTLA) is a protein from Homo sapiens identified by UniProt accession Q7Z6A9, 289 residues long. MolForge cross-references it against 0 known binders and 278 disease associations.
- UniProt accession: Q7Z6A9; gene symbol BTLA.
- Organism: Homo sapiens.
- Length: 289 amino acids.
- Top disease associations (Open Targets): eosinophil count, eosinophil percentage of leukocytes and coronary artery disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | B- and T-lymphocyte attenuator |
|---|---|
| UniProt accession | Q7Z6A9 |
| Gene | BTLA |
| Organism | Homo sapiens |
| Length | 289 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (278)
Diseases linked to this target (Open Targets).
- eosinophil count · score 0.31
- eosinophil percentage of leukocytes · score 0.25
- coronary artery disease · score 0.15
- neoplasm · score 0.11
- chronic lymphocytic leukemia · score 0.11
- Sepsis · score 0.10
- non-small cell lung carcinoma · score 0.10
- cancer · score 0.09
- pulmonary tuberculosis · score 0.09
- Systemic lupus erythematosus · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z6A9-F1 | alphafold | PREDICTED | 67.21 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z6A9.
Amino-acid sequence (289 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with BTLA?
The strongest Open Targets associations for BTLA are eosinophil count, eosinophil percentage of leukocytes, coronary artery disease, neoplasm and chronic lymphocytic leukemia.
How long is the BTLA protein?
The Homo sapiens BTLA protein (UniProt Q7Z6A9) is 289 amino acids long.
Browse: Targets: B · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z6A9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z6A9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.