SLIT-ROBO Rho GTPase-activating protein 1 (SRGAP1)
Homo sapiens — UniProt Q7Z6B7
Data last refreshed: (UniProt release unknown)
Key facts
SLIT-ROBO Rho GTPase-activating protein 1 (SRGAP1) is a protein from Homo sapiens identified by UniProt accession Q7Z6B7, 1085 residues long. MolForge cross-references it against 0 known binders and 59 disease associations.
- UniProt accession: Q7Z6B7; gene symbol SRGAP1.
- Organism: Homo sapiens.
- Length: 1085 amino acids.
- Top disease associations (Open Targets): follicular thyroid carcinoma, congenital hydronephrosis and congenital anomaly of kidney and urinary tract.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | SLIT-ROBO Rho GTPase-activating protein 1 |
|---|---|
| UniProt accession | Q7Z6B7 |
| Gene | SRGAP1 |
| Organism | Homo sapiens |
| Length | 1085 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (59)
Diseases linked to this target (Open Targets).
- follicular thyroid carcinoma · score 0.54
- congenital hydronephrosis · score 0.43
- congenital anomaly of kidney and urinary tract · score 0.43
- PR interval · score 0.36
- body mass index · score 0.30
- adolescent idiopathic scoliosis · score 0.29
- body fat percentage · score 0.29
- cystatin C measurement · score 0.26
- body height · score 0.24
- pancreatic adenocarcinoma · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z6B7-F1 | alphafold | PREDICTED | 72.63 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z6B7.
Amino-acid sequence (1085 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SRGAP1?
The strongest Open Targets associations for SRGAP1 are follicular thyroid carcinoma, congenital hydronephrosis, congenital anomaly of kidney and urinary tract, PR interval and body mass index.
How long is the SRGAP1 protein?
The Homo sapiens SRGAP1 protein (UniProt Q7Z6B7) is 1085 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z6B7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z6B7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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