N-terminal EF-hand calcium-binding protein 2 (NECAB2)
Homo sapiens — UniProt Q7Z6G3
Data last refreshed: (UniProt release unknown)
Key facts
N-terminal EF-hand calcium-binding protein 2 (NECAB2) is a protein from Homo sapiens identified by UniProt accession Q7Z6G3, 386 residues long. MolForge cross-references it against 0 known binders and 97 disease associations.
- UniProt accession: Q7Z6G3; gene symbol NECAB2.
- Organism: Homo sapiens.
- Length: 386 amino acids.
- Top disease associations (Open Targets): rheumatoid arthritis, alkaline phosphatase measurement and azoospermia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | N-terminal EF-hand calcium-binding protein 2 |
|---|---|
| UniProt accession | Q7Z6G3 |
| Gene | NECAB2 |
| Organism | Homo sapiens |
| Length | 386 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (97)
Diseases linked to this target (Open Targets).
- rheumatoid arthritis · score 0.29
- alkaline phosphatase measurement · score 0.14
- azoospermia · score 0.09
- low density lipoprotein cholesterol measurement · score 0.08
- apolipoprotein B measurement · score 0.08
- male infertility with teratozoospermia due to single gene mutation · score 0.08
- serum albumin measurement · score 0.07
- plasma fibronectin deficiency · score 0.07
- total cholesterol measurement · score 0.07
- sex hormone-binding globulin measurement · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z6G3-F1 | alphafold | PREDICTED | 73.44 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z6G3.
Amino-acid sequence (386 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NECAB2?
The strongest Open Targets associations for NECAB2 are rheumatoid arthritis, alkaline phosphatase measurement, azoospermia, low density lipoprotein cholesterol measurement and apolipoprotein B measurement.
How long is the NECAB2 protein?
The Homo sapiens NECAB2 protein (UniProt Q7Z6G3) is 386 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z6G3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z6G3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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