Spermatogenesis-associated protein 12 (SPATA12)
Homo sapiens — UniProt Q7Z6I5
Data last refreshed: (UniProt release unknown)
Key facts
Spermatogenesis-associated protein 12 (SPATA12) is a protein from Homo sapiens identified by UniProt accession Q7Z6I5, 190 residues long. MolForge cross-references it against 0 known binders and 23 disease associations.
- UniProt accession: Q7Z6I5; gene symbol SPATA12.
- Organism: Homo sapiens.
- Length: 190 amino acids.
- Top disease associations (Open Targets): platelet count, mean platelet volume and platelet crit.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Spermatogenesis-associated protein 12 |
|---|---|
| UniProt accession | Q7Z6I5 |
| Gene | SPATA12 |
| Organism | Homo sapiens |
| Length | 190 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (23)
Diseases linked to this target (Open Targets).
- platelet count · score 0.10
- mean platelet volume · score 0.09
- platelet crit · score 0.09
- platelet component distribution width · score 0.08
- adolescent idiopathic scoliosis · score 0.07
- body height · score 0.05
- eosinophil percentage of leukocytes · score 0.04
- cerebrospinal fluid biomarker measurement · score 0.04
- IGF-1 measurement · score 0.04
- diffuse plaque measurement · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z6I5-F1 | alphafold | PREDICTED | 42.55 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z6I5.
Amino-acid sequence (190 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SPATA12?
The strongest Open Targets associations for SPATA12 are platelet count, mean platelet volume, platelet crit, platelet component distribution width and adolescent idiopathic scoliosis.
How long is the SPATA12 protein?
The Homo sapiens SPATA12 protein (UniProt Q7Z6I5) is 190 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z6I5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z6I5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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