Rho GTPase-activating protein 30 (ARHGAP30)
Homo sapiens — UniProt Q7Z6I6
Data last refreshed: (UniProt release unknown)
Key facts
Rho GTPase-activating protein 30 (ARHGAP30) is a protein from Homo sapiens identified by UniProt accession Q7Z6I6, 1101 residues long. MolForge cross-references it against 0 known binders and 84 disease associations.
- UniProt accession: Q7Z6I6; gene symbol ARHGAP30.
- Organism: Homo sapiens.
- Length: 1101 amino acids.
- Top disease associations (Open Targets): monocyte count, monocyte percentage of leukocytes and leukocyte count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Rho GTPase-activating protein 30 |
|---|---|
| UniProt accession | Q7Z6I6 |
| Gene | ARHGAP30 |
| Organism | Homo sapiens |
| Length | 1101 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (84)
Diseases linked to this target (Open Targets).
- monocyte count · score 0.25
- monocyte percentage of leukocytes · score 0.19
- leukocyte count · score 0.17
- granulocyte percentage of myeloid white cells · score 0.17
- inflammatory bowel disease · score 0.16
- lung adenocarcinoma · score 0.09
- hemoglobin E-beta-thalassemia syndrome · score 0.05
- neoplasm · score 0.05
- hemoglobin D disease · score 0.05
- beta-thalassemia-X-linked thrombocytopenia syndrome · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z6I6-F1 | alphafold | PREDICTED | 50.02 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z6I6.
Amino-acid sequence (1101 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ARHGAP30?
The strongest Open Targets associations for ARHGAP30 are monocyte count, monocyte percentage of leukocytes, leukocyte count, granulocyte percentage of myeloid white cells and inflammatory bowel disease.
How long is the ARHGAP30 protein?
The Homo sapiens ARHGAP30 protein (UniProt Q7Z6I6) is 1101 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z6I6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z6I6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.