E3 ubiquitin-protein ligase SH3RF1 (SH3RF1)
Homo sapiens — UniProt Q7Z6J0
Data last refreshed: (UniProt release unknown)
Key facts
E3 ubiquitin-protein ligase SH3RF1 (SH3RF1) is a protein from Homo sapiens identified by UniProt accession Q7Z6J0, 888 residues long. MolForge cross-references it against 0 known binders and 44 disease associations.
- UniProt accession: Q7Z6J0; gene symbol SH3RF1.
- Organism: Homo sapiens.
- Length: 888 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, schizophrenia and forced expiratory volume.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | E3 ubiquitin-protein ligase SH3RF1 |
|---|---|
| UniProt accession | Q7Z6J0 |
| Gene | SH3RF1 |
| Organism | Homo sapiens |
| Length | 888 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (44)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.30
- schizophrenia · score 0.26
- forced expiratory volume · score 0.26
- peak expiratory flow · score 0.23
- self reported educational attainment · score 0.19
- intelligence · score 0.19
- clear cell renal carcinoma · score 0.18
- autosomal dominant compelling helio-ophthalmic outburst syndrome · score 0.18
- daytime rest measurement · score 0.16
- drug use measurement · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z6J0-F1 | alphafold | PREDICTED | 57.43 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z6J0.
Amino-acid sequence (888 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SH3RF1?
The strongest Open Targets associations for SH3RF1 are neurodegenerative disease, schizophrenia, forced expiratory volume, peak expiratory flow and self reported educational attainment.
How long is the SH3RF1 protein?
The Homo sapiens SH3RF1 protein (UniProt Q7Z6J0) is 888 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z6J0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z6J0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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