FYVE, RhoGEF and PH domain-containing protein 2 (FGD2)
Homo sapiens — UniProt Q7Z6J4
Data last refreshed: (UniProt release unknown)
Key facts
FYVE, RhoGEF and PH domain-containing protein 2 (FGD2) is a protein from Homo sapiens identified by UniProt accession Q7Z6J4, 655 residues long. MolForge cross-references it against 0 known binders and 57 disease associations.
- UniProt accession: Q7Z6J4; gene symbol FGD2.
- Organism: Homo sapiens.
- Length: 655 amino acids.
- Top disease associations (Open Targets): monocyte count, hypothyroidism and hemoglobin measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | FYVE, RhoGEF and PH domain-containing protein 2 |
|---|---|
| UniProt accession | Q7Z6J4 |
| Gene | FGD2 |
| Organism | Homo sapiens |
| Length | 655 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (57)
Diseases linked to this target (Open Targets).
- monocyte count · score 0.40
- hypothyroidism · score 0.37
- hemoglobin measurement · score 0.33
- erythrocyte count · score 0.31
- low density lipoprotein cholesterol measurement · score 0.30
- Thyroid preparation use measurement · score 0.30
- apolipoprotein B measurement · score 0.27
- hematocrit · score 0.27
- total cholesterol measurement · score 0.26
- monocyte percentage of leukocytes · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z6J4-F1 | alphafold | PREDICTED | 76.37 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z6J4.
Amino-acid sequence (655 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with FGD2?
The strongest Open Targets associations for FGD2 are monocyte count, hypothyroidism, hemoglobin measurement, erythrocyte count and low density lipoprotein cholesterol measurement.
How long is the FGD2 protein?
The Homo sapiens FGD2 protein (UniProt Q7Z6J4) is 655 amino acids long.
Browse: Targets: F · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z6J4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z6J4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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