E3 ubiquitin-protein ligase E3D (UBE3D)
Homo sapiens — UniProt Q7Z6J8
Data last refreshed: (UniProt release unknown)
Key facts
E3 ubiquitin-protein ligase E3D (UBE3D) is a protein from Homo sapiens identified by UniProt accession Q7Z6J8, 389 residues long. MolForge cross-references it against 0 known binders and 47 disease associations.
- UniProt accession: Q7Z6J8; gene symbol UBE3D.
- Organism: Homo sapiens.
- Length: 389 amino acids.
- Top disease associations (Open Targets): heel bone mineral density, neurodegenerative disease and body height.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | E3 ubiquitin-protein ligase E3D |
|---|---|
| UniProt accession | Q7Z6J8 |
| Gene | UBE3D |
| Organism | Homo sapiens |
| Length | 389 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (47)
Diseases linked to this target (Open Targets).
- heel bone mineral density · score 0.51
- neurodegenerative disease · score 0.50
- body height · score 0.44
- bone quantitative ultrasound measurement · score 0.39
- Crohn's disease · score 0.31
- DNA methylation · score 0.17
- lean body mass · score 0.15
- fat body mass · score 0.15
- body mass index · score 0.14
- body weight · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z6J8-F1 | alphafold | PREDICTED | 79.15 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z6J8.
Amino-acid sequence (389 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with UBE3D?
The strongest Open Targets associations for UBE3D are heel bone mineral density, neurodegenerative disease, body height, bone quantitative ultrasound measurement and Crohn's disease.
How long is the UBE3D protein?
The Homo sapiens UBE3D protein (UniProt Q7Z6J8) is 389 amino acids long.
Browse: Targets: U · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z6J8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z6J8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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