tRNA-splicing endonuclease subunit Sen54 (TSEN54)
Homo sapiens — UniProt Q7Z6J9
Data last refreshed: (UniProt release unknown)
Key facts
tRNA-splicing endonuclease subunit Sen54 (TSEN54) is a protein from Homo sapiens identified by UniProt accession Q7Z6J9, 526 residues long. MolForge cross-references it against 0 known binders and 61 disease associations.
- UniProt accession: Q7Z6J9; gene symbol TSEN54.
- Organism: Homo sapiens.
- Length: 526 amino acids.
- Top disease associations (Open Targets): pontocerebellar hypoplasia type 4, pontocerebellar hypoplasia type 2A and pontocerebellar hypoplasia type 5.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | tRNA-splicing endonuclease subunit Sen54 |
|---|---|
| UniProt accession | Q7Z6J9 |
| Gene | TSEN54 |
| Organism | Homo sapiens |
| Length | 526 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (61)
Diseases linked to this target (Open Targets).
- pontocerebellar hypoplasia type 4 · score 0.80
- pontocerebellar hypoplasia type 2A · score 0.75
- pontocerebellar hypoplasia type 5 · score 0.63
- pontocerebellar hypoplasia · score 0.53
- Non-syndromic pontocerebellar hypoplasia · score 0.53
- genetic disorder · score 0.47
- Global developmental delay · score 0.43
- Methylmalonic acidemia with homocystinuria, type cblD · score 0.43
- methylmalonic aciduria and homocystinuria type cblD · score 0.43
- pontocerebellar hypoplasia type 2 · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z6J9-F1 | alphafold | PREDICTED | 72.36 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z6J9.
Amino-acid sequence (526 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TSEN54?
The strongest Open Targets associations for TSEN54 are pontocerebellar hypoplasia type 4, pontocerebellar hypoplasia type 2A, pontocerebellar hypoplasia type 5, pontocerebellar hypoplasia and Non-syndromic pontocerebellar hypoplasia.
How long is the TSEN54 protein?
The Homo sapiens TSEN54 protein (UniProt Q7Z6J9) is 526 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z6J9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z6J9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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