THAP domain-containing protein 5 (THAP5)
Homo sapiens — UniProt Q7Z6K1
Data last refreshed: (UniProt release unknown)
Key facts
THAP domain-containing protein 5 (THAP5) is a protein from Homo sapiens identified by UniProt accession Q7Z6K1, 395 residues long. MolForge cross-references it against 0 known binders and 15 disease associations.
- UniProt accession: Q7Z6K1; gene symbol THAP5.
- Organism: Homo sapiens.
- Length: 395 amino acids.
- Top disease associations (Open Targets): self reported educational attainment, neurodegenerative disease and protein measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | THAP domain-containing protein 5 |
|---|---|
| UniProt accession | Q7Z6K1 |
| Gene | THAP5 |
| Organism | Homo sapiens |
| Length | 395 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (15)
Diseases linked to this target (Open Targets).
- self reported educational attainment · score 0.31
- neurodegenerative disease · score 0.22
- protein measurement · score 0.22
- alkaline phosphatase measurement · score 0.14
- insomnia measurement · score 0.06
- melanoma · score 0.01
- coronary artery disease · score 0.00
- hepatocellular carcinoma · score 0.00
- chronic kidney disease · score 0.00
- neoplasm · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z6K1-F1 | alphafold | PREDICTED | 58.49 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z6K1.
Amino-acid sequence (395 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with THAP5?
The strongest Open Targets associations for THAP5 are self reported educational attainment, neurodegenerative disease, protein measurement, alkaline phosphatase measurement and insomnia measurement.
How long is the THAP5 protein?
The Homo sapiens THAP5 protein (UniProt Q7Z6K1) is 395 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z6K1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z6K1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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