Notch-regulated ankyrin repeat-containing protein (NRARP)
Homo sapiens — UniProt Q7Z6K4
Data last refreshed: (UniProt release unknown)
Key facts
Notch-regulated ankyrin repeat-containing protein (NRARP) is a protein from Homo sapiens identified by UniProt accession Q7Z6K4, 114 residues long. MolForge cross-references it against 0 known binders and 98 disease associations.
- UniProt accession: Q7Z6K4; gene symbol NRARP.
- Organism: Homo sapiens.
- Length: 114 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, autosomal recessive spondylocostal dysostosis and diastolic blood pressure.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Notch-regulated ankyrin repeat-containing protein |
|---|---|
| UniProt accession | Q7Z6K4 |
| Gene | NRARP |
| Organism | Homo sapiens |
| Length | 114 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (98)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.54
- autosomal recessive spondylocostal dysostosis · score 0.08
- diastolic blood pressure · score 0.08
- posterior fusion of lumbosacral vertebrae-blepharoptosis syndrome · score 0.08
- macula measurement · score 0.08
- autosomal dominant spondylocostal dysostosis · score 0.08
- acute lymphoblastic leukemia · score 0.08
- ulcerative colitis · score 0.08
- microcephaly-cervical spine fusion anomalies syndrome · score 0.07
- Posterior fusion of lumbosacral vertebrae - blepharoptosis · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z6K4-F1 | alphafold | PREDICTED | 83.87 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z6K4.
Amino-acid sequence (114 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NRARP?
The strongest Open Targets associations for NRARP are neurodegenerative disease, autosomal recessive spondylocostal dysostosis, diastolic blood pressure, posterior fusion of lumbosacral vertebrae-blepharoptosis syndrome and macula measurement.
How long is the NRARP protein?
The Homo sapiens NRARP protein (UniProt Q7Z6K4) is 114 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z6K4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z6K4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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