Proline-rich transmembrane protein 2 (PRRT2)
Homo sapiens — UniProt Q7Z6L0
Data last refreshed: (UniProt release unknown)
Key facts
Proline-rich transmembrane protein 2 (PRRT2) is a protein from Homo sapiens identified by UniProt accession Q7Z6L0, 340 residues long. MolForge cross-references it against 0 known binders and 255 disease associations.
- UniProt accession: Q7Z6L0; gene symbol PRRT2.
- Organism: Homo sapiens.
- Length: 340 amino acids.
- Top disease associations (Open Targets): infantile convulsions and choreoathetosis, episodic kinesigenic dyskinesia 1 and benign familial infantile epilepsy.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Proline-rich transmembrane protein 2 |
|---|---|
| UniProt accession | Q7Z6L0 |
| Gene | PRRT2 |
| Organism | Homo sapiens |
| Length | 340 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (255)
Diseases linked to this target (Open Targets).
- infantile convulsions and choreoathetosis · score 0.81
- episodic kinesigenic dyskinesia 1 · score 0.80
- benign familial infantile epilepsy · score 0.74
- episodic kinesigenic dyskinesia · score 0.73
- genetic disorder · score 0.51
- neurodegenerative disease · score 0.46
- Seizure · score 0.45
- autosomal recessive non-syndromic intellectual disability · score 0.42
- Paroxysmal exertion-induced dyskinesia · score 0.38
- paroxysmal nonkinesigenic dyskinesia · score 0.38
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z6L0-F1 | alphafold | PREDICTED | 51.65 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z6L0.
Amino-acid sequence (340 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PRRT2?
The strongest Open Targets associations for PRRT2 are infantile convulsions and choreoathetosis, episodic kinesigenic dyskinesia 1, benign familial infantile epilepsy, episodic kinesigenic dyskinesia and genetic disorder.
How long is the PRRT2 protein?
The Homo sapiens PRRT2 protein (UniProt Q7Z6L0) is 340 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z6L0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z6L0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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