Rab9 effector protein with kelch motifs (RABEPK)
Homo sapiens — UniProt Q7Z6M1
Data last refreshed: (UniProt release unknown)
Key facts
Rab9 effector protein with kelch motifs (RABEPK) is a protein from Homo sapiens identified by UniProt accession Q7Z6M1, 372 residues long. MolForge cross-references it against 0 known binders and 39 disease associations.
- UniProt accession: Q7Z6M1; gene symbol RABEPK.
- Organism: Homo sapiens.
- Length: 372 amino acids.
- Top disease associations (Open Targets): pulse pressure measurement, systolic blood pressure and neuroticism measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Rab9 effector protein with kelch motifs |
|---|---|
| UniProt accession | Q7Z6M1 |
| Gene | RABEPK |
| Organism | Homo sapiens |
| Length | 372 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (39)
Diseases linked to this target (Open Targets).
- pulse pressure measurement · score 0.38
- systolic blood pressure · score 0.37
- neuroticism measurement · score 0.12
- worry measurement · score 0.11
- pathological myopia · score 0.11
- Myopia · score 0.11
- anxiety measurement · score 0.10
- appendicular lean mass · score 0.10
- cigarettes per day measurement · score 0.08
- smoking cessation · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q7Z6M1-F1 | alphafold | PREDICTED | 89.27 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q7Z6M1.
Amino-acid sequence (372 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RABEPK?
The strongest Open Targets associations for RABEPK are pulse pressure measurement, systolic blood pressure, neuroticism measurement, worry measurement and pathological myopia.
How long is the RABEPK protein?
The Homo sapiens RABEPK protein (UniProt Q7Z6M1) is 372 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q7Z6M1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q7Z6M1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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